Electrolyzed and Natural Reduced Water Exhibit Insulin-Like Activity on Glucose Uptake into Muscle Cells and Adipocytes

Veröffentlicht 1999 Japan H. Hayashi K. Kusumoto K. Otsubo K. Teruya M. Oda S. Kabayama S. Morisawa Sanetaka Shirahata T. Hara T. Maki Y. Ishii Y. Katakura Cell Culture Animal Cell Technology: Products from Cells Cells as Products Culture Media Positive Whole Body Diabetes (Type II) Glucose Metabolism Water (Electrolysis)

In the type 2 diabetes, it has become clear that reactive oxygen species (ROS) cause reduction of glucose uptake by inhibiting the insulin-signaling pathway in muscle cells and adipocytes. We demonstrated that electrolyzed-reduced water (ERW) scavenges ROS and protects DNA from oxidative damage1). Here we found that ERW scavenges ROS in insulin-responsive L6 myotubes and mouse3T3/L1 adipocytes. Uptake of 1-deoxy-D- glucose (2-DOG) into both L6 cells and 3T3/L1 cells was stimulated by ERW in the presence or absence of insulin. This insulin-like activity of ERW was mediated by the activation of PI-3 kinase, resulting in stimulation of translocation of glucose transporter GLUT4 from microsome to plasma membrane. These results suggest that ERW may be useful to improve insulin-independent type 2 diabetes.

Mehr lesen: https://doi.org/10.1007/0-306-46875-1_90

Electrolyzed and Natural Reduced Water Exhibit Insulin-Like Activity on Glucose Uptake into Muscle Cells and Adipocytes

Veröffentlicht 1999 Positive Whole Body Diabetes (Type II) Glucose Metabolism

In the type 2 diabetes, it has become clear that reactive oxygen species (ROS) cause reduction of glucose uptake by inhibiting the insulin-signaling pathway in muscle cells and adipocytes. We demonstrated that electrolyzed-reduced water (ERW) scavenges ROS and...

Anti-Oxidative Water Improves Diabetes

Veröffentlicht 2001 Positive Whole Body Diabetes (Type II) Oxidative Stress

Electrolyzed reduced water and natural waters such as Hita Tenryosui water in Japan, Nordenau water in Germany and Tracote water in Mexico, which are known to improve various diseases, were all and- oxidative waters which could scavenge intracellular reactive oxygen...

Changes in the Relevant Test Parameters of 101 Diabetes Patients under the Influence of the So-Called “Nordenau-Phenomenon”

Veröffentlicht 2002 Positive Whole Body Diabetes (Type II) Oxidative Stress

The study examined changes in the test parameters of 101 diabetes patients (56 female, 45 male) under the influence of what is known as the “Nordenau Phenomenon”, which attributes a healing effect to an old slate tunnel with an underground spring. The average age of...

Influence of natural reduced water on relevant tests parameters and reactive oxygen species concentration in blood of 320 diabetes patients in the prospective observation procedure

Veröffentlicht 2006 Positive Whole Body Diabetes (Type II) Oxidative Stress

The study examined changes in the relevant tests parameters of 320 diabetes patients (176 female, 144 male) drinking natural reduced water from the ‚Nordenau Spring‘ in Nordenau, Germany as well as the correlation of these changes with the fluctuation of...

Electrolyzed and Natural Reduced Water Exhibit Insulin-Like Activity on Glucose Uptake into Muscle Cells and Adipocytes